Hao Chen

About

Dr. Hao Chen obtained his Ph.D. from the Chinese University of Hong Kong and is currently a professor at Guangzhou Medical University. His lab studies the physiology of the male reproductive system and related diseases associated with human infertility.

Work

Guangzhou Medical University

|

Professor

China

→

Nantong University

|

Professor

China

→

Publications

Blocking T-type calcium channels disrupts spermatogenesis in vivo and adversely affects spermatocytes in vitro by impairing mitochondrial function and autophagic flux

Reproductive Toxicology

journal-article

METTL5 deficiency induces oligoasthenoteratozoospermia via impaired 18S rRNA m6A methylation in humans and mice

Molecular Therapy

journal-article

Single-cell RNA sequencing uncovers abnormal Sertoli-cell elevation and testicular niche impairment in the transfemales’s testis

Cell & Bioscience

journal-article

PCP protein Prickle 1 regulates Sertoli cell and testis function via cytoskeletal organization through the recruitment of multiple regulatory proteins

American Journal of Physiology-Cell Physiology

journal-article

Advances in Imaging Techniques for Mammalian/Human Ciliated Cell’s Cilia: Insights into Structure, Function, and Dynamics

Biology

journal-article

Advances in Imaging Techniques for Mammalian/Human Ciliated Cell’s Cilia: Insights into Structure, Function, and Dynamics

Biology

journal-article

In situ architecture of the intercellular organelle reservoir between epididymal epithelial cells by volume electron microscopy

Nature Communications

journal-article

Advancement and Potential Applications of Epididymal Organoids

Biomolecules

journal-article

Advancement and Potential Applications of Epididymal Organoids

Biomolecules

journal-article

Unraveling the ultrastructure and dynamics of autophagic vesicles: Insights from advanced imaging techniques

FASEB BioAdvances

journal-article

Unlocking Genetic Mysteries during the Epic Sperm Journey toward Fertilization: Further Expanding Cre Mouse Lines

Biomolecules

journal-article

Unlocking Genetic Mysteries during the Epic Sperm Journey toward Fertilization: Further Expanding Cre Mouse Lines

Biomolecules

journal-article

Map-1a regulates Sertoli cell BTB dynamics through the cytoskeletal organization of microtubule and F-actin

Reproductive Biology and Endocrinology

journal-article

Exposure to Titanium Dioxide Nanoparticles Leads to Specific Disorders of Spermatid Elongation via Multiple Metabolic Pathways in Drosophila Testes

ACS Omega

journal-article

LncRNA USP2-AS1 facilitates the osteogenic differentiation of bone marrow mesenchymal stem cells by targeting KDM3A/ETS1/USP2 to activate the Wnt/β-catenin signaling pathway

RNA Biology

journal-article

Structure and molecular basis of spermatid elongation in the Drosophila testis

Open Biology

journal-article

Connecting the Dots: N6‐Methyladenosine (m6A) Modification in Spermatogenesis

Advanced Biology

journal-article

Cadmium-induced Sertoli Cell Injury Through p38-MAPK and Related Signaling Proteins—A Study by RNA Sequencing

Endocrinology

journal-article

Epididymis cell atlas in a patient with a sex development disorder and a novel NR5A1 gene mutation

Asian Journal of Andrology

journal-article

SARS-CoV-2 and male infertility: from short- to long-term impacts

Journal of Endocrinological Investigation

journal-article

SARS-CoV-2 and male infertility: from short- to long-term impacts

Journal of Endocrinological Investigation

journal-article

β-Defensin 19/119 mediates sperm chemotaxis and is associated with idiopathic infertility

Cell Reports Medicine

journal-article

Defb19 regulates the migration of germ cell and is involved in male fertility

Cell & Bioscience

journal-article

CSE1L/CAS regulates cell proliferation through CDK signalling in mouse spermatogenesis

Cell Proliferation

journal-article

The N501Y Mutation of SARS-CoV-2 Spike Protein Impairs Spindle Assembly in Mouse Oocytes

Reproductive Sciences

journal-article

Interfering with CSE1L/CAS inhibits tumour growth via C3 in triple‐negative breast cancer

Cell Proliferation

journal-article

Cell-Cell Interaction-Mediated Signaling in the Testis Induces Reproductive Dysfunction-Lesson from the Toxicant/Pharmaceutical Models

Cells

journal-article

The effects of thirdhand smoke on reproductive health

Journal of Applied Toxicology

journal-article

The repertoire of testicular extracellular vesicle cargoes and their involvement in inter-compartmental communication associated with spermatogenesis

BMC Biology

journal-article

CD147 deficiency is associated with impaired sperm motility/acrosome reaction and offers a therapeutic target for asthenozoospermia

Molecular Therapy - Nucleic Acids

journal-article

Spatio-temporal landscape of mouse epididymal cells and specific mitochondria-rich segments defined by large-scale single-cell RNA-seq

Cell Discovery

journal-article

Spatio-temporal landscape of mouse epididymal cells and specific mitochondria-rich segments defined by large-scale single-cell RNA-seq

Cell Discovery

journal-article

Epididymal initial segment-specific Cre recombinase activity in Lcn8-Cre knock-in mice

Molecular Biology Reports

journal-article

Cellular apoptosis susceptibility protein (CAS) suppresses the proliferation of breast cancer cells by upregulated cyp24a1

Medical Oncology

journal-article

An alternative splicing variant of mineralocorticoid receptor discovered in preeclampsia tissues and its effect on endothelial dysfunction

Science China Life Sciences

journal-article

The landscape of mouse epididymal cells defined by the single-cell RNA-Seq

preprint

Impairment of spermatogenesis and sperm motility by the high-fat diet-induced dysbiosis of gut microbes

Gut

journal-article

Expression of cellular apoptosis susceptibility (CAS) in the human testis and testicular germ cell tumors

Medical Oncology

journal-article

Defective CFTR promotes intestinal proliferation via inhibition of the hedgehog pathway during cystic fibrosis

Cancer Letters

journal-article

MRP4 sustains Wnt/β-catenin signaling for pregnancy, endometriosis and endometrial cancer

Theranostics

journal-article

CD147 Induces Epithelial-to-Mesenchymal Transition by Disassembling Cellular Apoptosis Susceptibility Protein/E-Cadherin/β-Catenin Complex in Human Endometriosis

The American Journal of Pathology

journal-article

CCR6 is required for ligand-induced CatSper activation in human sperm

Oncotarget

journal-article

Upregulation of CFTR in patients with endometriosis and its involvement in NFκB-uPAR dependent cell migration

Oncotarget

journal-article

CD147 regulates extrinsic apoptosis in spermatocytes by modulating NF kappa B signaling pathways

Oncotarget

journal-article

Generation of scFv specific to human VEGFR-3 from the neutralizing mAb BDD073

Protein Engineering Design and Selection

journal-article

Up-regulation of Bcl-2 by CD147 Through ERK Activation Results in Abnormal Cell Survival in Human Endometriosis

Journal of Clinical Endocrinology & Metabolism

journal-article

Deficient human beta-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection

Science Translational Medicine

journal-article

Elevated expression of CD147 in patients with endometriosis and its role in regulating apoptosis and migration of human endometrial cells

Fertility and Sterility

journal-article

Novel regulators of spermatogenesis

Seminars in Cell & Developmental Biology

journal-article

Reconstitution of coronary vasculature by an active fraction of Geum japonicum in ischemic hearts

Scientific Reports

journal-article

Decreased expression of cystic fibrosis transmembrane conductance regulator impairs sperm quality in aged men

Reproduction

journal-article

Downregulation of CFTR promotes epithelial-to-mesenchymal transition and is associated with poor prognosis of breast cancer

Biochimica Et Biophysica Acta-Molecular Cell Research

journal-article

Inhibition of angiogenesis by a novel neutralizing antibody targeting human VEGFR-3

Mabs

journal-article

Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation

Nature Genetics

journal-article

New insights into germ cell migration and survival/apoptosis in spermatogenesis

Spermatogenesis

journal-article

CD147 regulates apoptosis in mouse spermatocytes but not spermatogonia

Human Reproduction

journal-article

Lymphocyte CFTR promotes epithelial bicarbonate secretion for bacterial killing

Journal of Cellular Physiology

journal-article

Reconstitution of coronary vasculature in ischemic hearts by plant-derived angiogenic compounds

International Journal of Cardiology

journal-article

STK31 Maintains the Undifferentiated State of Colon Cancer Cells

Carcinogenesis

journal-article

CD147 is required for matrix metalloproteinases-2 production and germ cell migration during spermatogenesis

Molecular Human Reproduction

journal-article

Lymphocytes Accelerate Epithelial Tight Junction Assembly: Role of AMP-Activated Protein Kinase (AMPK)

Plos One

journal-article

A Plant-Derived Remedy for Repair of Infarcted Heart

Plos One

journal-article